XULAneXUS

Welcome to XULAneXUS! First published in 2002, XULAneXUS is a peer-reviewed online journal that publishes the scholarship of Xavier University of Louisiana undergraduates. The journal is sponsored by the Center for Undergraduate Research and Graduate Opportunity and funded in part by the Andrew W. Mellon Foundation.

Current Issue

Volume 22, Issue 1 (2025)View issue

Current Articles

    • Article15 April 2025

      Missense Mutation of Msh6 Leucine 696 Has No Apparent Effect on the DNA Mismatch Repair Process

      Lynch Syndrome and Constitutional Mismatch Repair Deficiency are human diseases implicated in mutations of DNA mismatch repair (MMR) genes. This experiment tested a mutation of an MMR gene, MSH6, and evaluated how the mutation affected overall MMR effectiveness. Using the yeast Saccharomyces cerevisiae, we performed the CAN1 forward mutation assay to study msh6-L696F and its implications in the MMR process. We hypothesized that there would be a significant change in molecular function in the Msh6 protein in the presence of this mutation. Bioinformatic tools predicted that this amino acid change would have deleterious effects on MMR function. However, this allele seems to have no apparent effect on the proficiency of overall DNA MMR capabilities.

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