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Description

Double minute chromosomes are fragments of extrachromosomal DNA found in various cancer subtypes. The formation of double minute chromosomes causes gene amplification which then results in the overexpression of cellular oncogenes. Their mechanism of formation is poorly understood, but analysis of DNA sequencing data can potentially uncover evidence of hypothesized mechanisms of their formation. In this study, we use the whole genome sequencing data of non-solid tumor genomes to study double minute chromosomes and investigate features that support the deletion-episome model of their formation.

Publication Date

2021

City

New Orleans

Keywords

Cancer Genomes, eccDNA, Double Minute Chromosome Formation.

Disciplines

Biology | Genetics and Genomics | Life Sciences | Medicine and Health Sciences | Oncology

Cancer Genomes with eccDNA Oncogene Amplification Show Evidence of Deletion-Episome Model of Double Minute Chromosome Formation

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