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Description

Double minute chromosomes ( are small, circular fragments of highly amplified extrachromosomal DNA that harbor oncogenes (Figure 1 If DMs are reduced, this can decrease the malignancy of cancer and potentially prolong life and/or positively affect quality of life In order to reduce DMs they must first be detected The visualization of Hi C sequencing data makes it possible to infer DMs based on their chromatin touch patterns However, statistical analyses of Hi C touch patterns can potentially reduce false positives in algorithms that predict the location of DM amplicons in Hi C data The purpose of this research is to statistically quantify the confidence of predicted double minute amplicons using Hi C sequencing data

Publication Date

2021

City

New Orleans

Keywords

Quantifying Double Minute Chromosome, Touch Patterns, Hi C Sequencing Contact Maps

Disciplines

Biology | Computer Sciences | Life Sciences | Physical Sciences and Mathematics | Physics | Public Health

Quantifying Double Minute Chromosome Touch Patterns in Hi C Sequencing Contact Maps

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