Title

Role of Cytochrome C in Apoptosis During Breast Cancer Treatment

Authors

Teresa Beamon, Department of Chemistry, Xavier University of Louisiana
Royce Hooks, Department of Chemistry, Xavier University of Louisiana
Degrick Cheatham, Department of Chemistry, Xavier University of Louisiana
Navneet Goyal, Department of Chemistry, Xavier University of Louisiana
Tulasi Ponnapakkam, Department of Chemistry, Xavier University of Louisiana
Maryam Foroozesh, Department of Chemistry, Xavier University of Louisiana

Files

Description

Breast cancer is the leading cause of death in women. Various current cancer treatments include surgery, chemotherapy, immunotherapy, hormone therapy, and radiation therapy. Because of prolonged exposure, resistance to chemotherapy often arises. Chemotherapeutic drugs and radiation therapy have been shown to increase intracellular ceramide levels. Ceramide, a bioactive sphingolipid, is a powerful tumor suppressor molecule that is thought to induce apoptosis and inhibit proliferation.

As part of our ongoing efforts toward the synthesis of a potent anti-cancer drug, ceramide analog 315, (S,E)-3-hydroxy-2-(2-hydroxybenzylidene)amino-Ntetradecyl propanamide has been synthesized. Ceramide analog 315 has been shown to induce apoptosis in vitro, and decrease tumor volume and size in in vivo studies. In the present study, an attempt is made to corelate the cytochrome C levels with cell death during the treatment of chemo-resistant breast cancer cells with analog 315.

Publication Date

2021

City

New Orleans

Keywords

Cytochrome C, Apoptosis, Breast Cancer, Treatment

Disciplines

Chemistry | Laboratory and Basic Science Research | Medicine and Health Sciences | Oncology

Recommended Citation

Beamon, Teresa; Hooks, Royce; Cheatham, Degrick; Goyal, Navneet; Ponnapakkam, Tulasi; and Foroozesh, Maryam, "Role of Cytochrome C in Apoptosis During Breast Cancer Treatment" (2021). Festival of Scholars. 15.
https://digitalcommons.xula.edu/xula_fos/15