Title

Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases

Authors

J. M. Webre, Louisiana State University Health Sciences Center New Orleans
J. M. Hill, Louisiana State University Health Sciences Center New Orleans
N. M. Nolan, Louisiana State University Health Sciences Center New Orleans
C. Clement, Louisiana State University Health Sciences Center New Orleans
H. McFerrin, Xavier University of LouisianaFollow
Partha S. Bhattacharjee, Xavier University of LouisianaFollow
V. Hsia, University of Maryland Eastern Shore, Princess Anne, MD
D. M. Neumann, Louisiana State University Health Sciences Center New Orleans
T. P. Foster, Louisiana State University Health Sciences Center New Orleans
W. J. Lukiw, Louisiana State University Health Sciences Center New Orleans
H. W. Thompson, Louisiana State University Health Sciences Center New Orleans

Funding Source

National Institutes of Health, National Eye Institute, National Center for Research Resources

Grant Number

R01-EY006311, R01-EY14289, R21-EY019144, R15-EY020803, AG18031, AG038834, AG23085, P20RR016456

Department

Department of Biology

Document Type

Article

Publication Date

10-2-2012

Abstract

The exact mechanisms of HSV-1 establishment, maintenance, latency, reactivation, and also the courses of recurrent ocular infections remain a mystery. Comprehensive understanding of the HSV-1 disease process could lead to prevention of HSV-1 acute infection, reactivation, and more effective treatments of recurrent ocular disease. Animal models have been used for over sixty years to investigate our concepts and hypotheses of HSV-1 diseases. In this paper we present descriptions and examples of rabbit and mouse eye models of HSV-1 latency, reactivation, and recurrent diseases. We summarize studies in animal models of spontaneous and induced HSV-1 reactivation and recurrent disease. Numerous stimuli that induce reactivation in mice and rabbits are described, as well as factors that inhibit viral reactivation from latency. The key features, advantages, and disadvantages of the mouse and rabbit models in relation to the study of ocular HSV-1 are discussed. This paper is pertinent but not intended to be all inclusive. We will give examples of key papers that have reported novel discoveries related to the review topics.

Comments

DOI: 10.1155/2012/612316

PubMed ID: 23091352

Recommended Citation

Webre, J. M.; Hill, J. M.; Nolan, N. M.; Clement, C.; McFerrin, H.; Bhattacharjee, Partha S.; Hsia, V.; Neumann, D. M.; Foster, T. P.; Lukiw, W. J.; and Thompson, H. W., "Rabbit and Mouse Models of HSV-1 Latency, Reactivation, and Recurrent Eye Diseases" (2012). Faculty and Staff Publications. 202.
https://digitalcommons.xula.edu/fac_pub/202