Title
Expression, Regulation and Function of miR-126 in the Mouse Choroid Vasculature.
Funding Source
Tulane University, National Institutes of Health, Research to Prevent Blindness
Grant Number
EY026069,EY021862
Department
Department of Biology
Document Type
Article
Publication Date
5-2018
Abstract
MicroRNA miR-126 has been shown to be required for proper angiogenesis in several models. However, its expression, regulation and function in the mouse choroid remain unclear. Our previous data has shown that miR-126 expression is enriched in the endothelial cells (ECs) of the mouse choroid. Here we report that a 5.5 kb Egfl7/miR-126 promoter drives the expression of miR-126 in the choroid ECs during choroidal vascular development. The expression of miR-126 in the ECs is regulated by flow stress likely through Krüppel-like transcriptional factors. miR-126−/− mice show mildly delayed choroidal vascular development, but adult knockout mice develop periphery choroidal vascular lesions. This study suggests that miR-126 is largely dispensable for mouse choroidal development but required for maintaining choroidal vasculature integrity.
Recommended Citation
Zhao, F.; Anderson, C.; Karnes, S.; Zhou, Q.; Ma, J.; Jin, Zhenggen; Bhattacharjee, Partha S.; and Wang, S., "Expression, Regulation and Function of miR-126 in the Mouse Choroid Vasculature." (2018). Faculty and Staff Publications. 200.
https://digitalcommons.xula.edu/fac_pub/200
Comments
DOI: 10.1016/j.exer.2018.02.026
PubMed ID: 29501382