Novel Synthesis of Divergent Aryl Imidazoles from Ketones Involving Copper-Catalyzed α-amination and Oxidative C-C Bond Cleavage
Higher Education Discipline Innovation Project, Sichuan University, National Natural Science Foundation of China
B18035, 2017 CDLZ-S34, 21072131
Department of Chemistry
A one-pot synthesis, initiated by a copper salt with inorganic (NH4)2CO3 as the nitrogen source, forms divergent aryl imidazole derivatives from ketones via a-amination and oxidative C–C bond cleavage reactions. The approach provides a simple and rapid synthesis of imidazole derivatives and has certain versatility.
Huang, J.; Luo, L.; Xing, N.; Liu, C.; Han, Q.; Zheng, Shilong; and He, L., "Novel Synthesis of Divergent Aryl Imidazoles from Ketones Involving Copper-Catalyzed α-amination and Oxidative C-C Bond Cleavage" (2020). Faculty and Staff Publications. 165.