Xavier University of Louisiana, National Institutes of Health
Department of Chemistry
Copper salt-catalyzed oxidative amination resulted in the formation of a novel series of triazole-spirodienone conjugates, 4-triazolyl-1-oxa-4-azaspiro[4,5]deca-6,9-dien-3,8-diones and 4-triazolyl-1-oxa-4-azaspiro[4,5]deca-6,9-dien-8-ones. A single crystal of compound 1p among them was grown and analyzed by X-ray crystallography. These compounds were evaluated for their antiproliferative activities against MDA-MB-231, HeLa, A549 and MCF-7 cell lines. Most of them showed moderate to high anticancer potency in the four cancer cell lines. The discovery of the triazole-spirodienone conjugates as cytotoxic agents against cancer cells may open up a new field in which these novel small molecules could be further explored as promising anticancer agents.
Gu, L.; Wang, P.; Zhong, Qiu; Deng, Y.; Xie, J.; Liu, F.; Xiao, F.; Zheng, Shilong; Chen, Y.; Wang, Guangdi; and He, L., "Copper Salt-Catalyzed Formation of a Novel Series of Triazole-Spirodienone Conjugates with Potent Anticancer Activity." (2017). Faculty and Staff Publications. 124.