Funding Source

Xavier University of Louisiana, National Institutes of Health

Grant Number

2013CDLZ-S18, 2G12MD007595-07


Department of Chemistry

Document Type


Publication Date



Copper salt-catalyzed oxidative amination resulted in the formation of a novel series of triazole-spirodienone conjugates, 4-triazolyl-1-oxa-4-azaspiro[4,5]deca-6,9-dien-3,8-diones and 4-triazolyl-1-oxa-4-azaspiro[4,5]deca-6,9-dien-8-ones. A single crystal of compound 1p among them was grown and analyzed by X-ray crystallography. These compounds were evaluated for their antiproliferative activities against MDA-MB-231, HeLa, A549 and MCF-7 cell lines. Most of them showed moderate to high anticancer potency in the four cancer cell lines. The discovery of the triazole-spirodienone conjugates as cytotoxic agents against cancer cells may open up a new field in which these novel small molecules could be further explored as promising anticancer agents.


DOI: 10.1039/c6ra24764d

Funding text

This work was supported by the Sichuan University-Lu Zhou Strategic Cooperation Projects (No. 2013CDLZ-S18) (Ling He) and the NIH RCMI program at Xavier University of Louisiana through Grant 2G12MD007595-07 (G. Wang).