Funding Source
Xavier University of Louisiana, National Institutes of Health
Grant Number
2013CDLZ-S18, 2G12MD007595-07
Department
Department of Chemistry
Document Type
Article
Publication Date
2017
Abstract
Copper salt-catalyzed oxidative amination resulted in the formation of a novel series of triazole-spirodienone conjugates, 4-triazolyl-1-oxa-4-azaspiro[4,5]deca-6,9-dien-3,8-diones and 4-triazolyl-1-oxa-4-azaspiro[4,5]deca-6,9-dien-8-ones. A single crystal of compound 1p among them was grown and analyzed by X-ray crystallography. These compounds were evaluated for their antiproliferative activities against MDA-MB-231, HeLa, A549 and MCF-7 cell lines. Most of them showed moderate to high anticancer potency in the four cancer cell lines. The discovery of the triazole-spirodienone conjugates as cytotoxic agents against cancer cells may open up a new field in which these novel small molecules could be further explored as promising anticancer agents.
Recommended Citation
Gu, L.; Wang, P.; Zhong, Qiu; Deng, Y.; Xie, J.; Liu, F.; Xiao, F.; Zheng, Shilong; Chen, Y.; Wang, Guangdi; and He, L., "Copper Salt-Catalyzed Formation of a Novel Series of Triazole-Spirodienone Conjugates with Potent Anticancer Activity." (2017). Faculty and Staff Publications. 124.
https://digitalcommons.xula.edu/fac_pub/124
Comments
DOI: 10.1039/c6ra24764d
Funding text
This work was supported by the Sichuan University-Lu Zhou Strategic Cooperation Projects (No. 2013CDLZ-S18) (Ling He) and the NIH RCMI program at Xavier University of Louisiana through Grant 2G12MD007595-07 (G. Wang).