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2,2-bis(methylol)propionic acid (bis-MPA) dendrimers are ideal backbones for novel drug delivery systems. Bis-MPA based dendrimers tend to be stable with multiple terminal groups with potential for functionalization, making them excellent for use in targeted drug delivery. However, these dendrimers have low water solubility. Amphiphilic block copolymers, a class of Stimuli Responsive Polymers (SRPs), can be conjugated to the end of the dendrimer. This increases the water solubility of the molecule while simultaneously increases the efficiency of SRPs. Water solubility can be further increased through the addition of polyethylene glycol (PEG) as linkages between the dendrimer and the SRP. The efficiency of free SRPs will be compared to the efficiency of the novel vehicle to determine if the proposed materials are viable as drug delivery systems.
Xavier University of Louisiana
bis-MPA, novel drug delivery
Ogbonna, Sharon; Derbigny, Blaine; Hodge, Greg; and DiMaggio, Stassi, "Using bis-MPA as a platform for novel drug delivery systems" (2020). Building Infrastructure Leading to Diversity (BUILD). 9.