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Cigarette smoking causes nearly one in every five deaths in the United States. The life expectancy of a smoker is 10 years less than a nonsmoker on average. Cigarette smoke contains more than 7,000 chemicals, seventy of which are known to cause cancer. Nicotine is responsible for the addictive and psychopharmacological effects of tobacco. Many tobacco components including nicotine are metabolized by cytochrome P450 enzymes. Nicotine is mainly metabolized by P450s 2A6 and 2A13. In this project, our goal is to design and synthesize selective metabolism-based inhibitors of P450 2A6. Such inhibitors can decrease the amount of tobacco chemicals metabolized into carcinogenic species. In addition, they can potentially be used for smoking cessation.
Xavier University of Louisiana
Tobacco Use Cessation, Cytochrome P450 2A6, Synthesis
Obioha, Chinyere; Do, Camilla; Ponnapakkam, Tulasi; Goyal, Navneet; and Foroozesh, Maryam, "Design & Synthesis of Small Molecules as Inhibitors of Cytochrome P450 2A6 for Tobacco Use Cessation" (2020). Building Infrastructure Leading to Diversity (BUILD). 4.