National Institutes of Health
Department of Chemistry
Fifteen novel N-triazol-5-yl-oxazolidin-4-ones were synthesized through a few of steps from the benzaldehydes. It was found that N-iodosuccinimide (NIS) can promote intramolecular amination reaction which is the key step of the syntheses, which will be used as new method for the intramolecular formation of nitrogen-containing heterocycles. Part of the compounds were evaluated for their anticancer activity. Among them, compounds 6a, 6b and 6c showed moderate antiprolifiration activity toward human breast cancer cells MDA-MB-231 cell lines, while the mild activity of 6a, 6b and 6d against human cervical cancer HeLa cell lines was confirmed in vitro assay.
Luo, R.; Guo, S.; Zheng, Shilong; Wang, Guangdi; Bao, X.; and He, L., "Synthesis and Antitumor Activity of N-Triazol-5-yl-oxazolidin-4-one Derivatives." (2017). Faculty and Staff Publications. 129.