Funding Source

National Institutes of Health

Grant Number

2013CDLZ-S18, 2G12MD007595-07


Department of Chemistry

Document Type


Publication Date



Fifteen novel N-triazol-5-yl-oxazolidin-4-ones were synthesized through a few of steps from the benzaldehydes. It was found that N-iodosuccinimide (NIS) can promote intramolecular amination reaction which is the key step of the syntheses, which will be used as new method for the intramolecular formation of nitrogen-containing heterocycles. Part of the compounds were evaluated for their anticancer activity. Among them, compounds 6a, 6b and 6c showed moderate antiprolifiration activity toward human breast cancer cells MDA-MB-231 cell lines, while the mild activity of 6a, 6b and 6d against human cervical cancer HeLa cell lines was confirmed in vitro assay.


DOI: 10.6023/cjoc201701053

Funding text

* Corresponding author. E-mail: Received February 6, 2017; revised March 27, 2017; published online May 2, 2017. Project supported by the Sichuan University-Lu Zhou Strategic Cooperation Projects (No. 2013CDLZ-S18), the NIH RCMI Program at Xavier Uni-versity of Louisiana through Grant (No. 2G12MD007595-07). 川大-泸州战略合作(No. 2013CDLZ-S18)和 NIMHD-RCMI (No. 5G12MD007595)资助项目.