Tetrahydroberberine, a Pharmacologically Active Naturally Occurring Alkaloid.
Department of Chemistry
Tetrahydroberberine (systematic name: 9,10-dimethoxy-5,8,13,13a-tetrahydro-6H-benzo[g][1,3]benzodioxolo[5,6-a]quinolizine), C20H21NO4, a widely distributed naturally occurring alkaloid, has been crystallized as a racemic mixture about an inversion center. A bent conformation of the molecule is observed, with an angle of 24.72(5)° between the arene rings at the two ends of the reduced quinolizinium core. The intermolecular hydrogen bonds that play an apparent role in crystal packing are 1,3-benzodioxole -CH2⋯OCH3 and -OCH3⋯OCH3 interactions between neighboring molecules.
Pingali, S.; Donahue, J. P.; and Payton-Stewart, Florastina, "Tetrahydroberberine, a Pharmacologically Active Naturally Occurring Alkaloid." (2015). Faculty and Staff Publications. 114.